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Nitrosylation results in a molecule "R" adducted with the group N=O

Nitrosylation is the general term for covalent incorporation of a nitric oxide (NO) moiety into another (usually organic) molecule. There are multiple chemical mechanisms by which this can be achieved, including enzymes and chemical synthesis. The biological functions of nitric oxide include S-nitrosylation, the conjugation of NO to cysteine thiols in proteins, which is an important part of cell signalling.[1] Coordination of NO to transition metals to give metal nitrosyl complexes is also referred to as nitrosylation.[2]

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  1. ^ Mannick, Joan B.; Schonhoff, Christopher M. (7 July 2009). "Review: NO Means No and Yes: Regulation of Cell Signaling by Protein Nitrosylation". Free Radical Research. 38 (1): 1–7. doi:10.1080/10715760310001629065. PMID 15061648. S2CID 21787778.
  2. ^ Hayton, T. W.; Legzdins, P.; Sharp, W. B. (2002). "Coordination and Organometallic Chemistry of Metal-NO Complexes". Chem. Rev. 102 (1): 935–991. doi:10.1021/cr000074t. PMID 11942784.