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Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
CAS Registry Number 54533-85-6
ATC code N06BX10
PubChem CID: 4514
ChemSpider 4357 YesY
Chemical data
Formula C21H21ClN4O3
Molecular mass 412.869 g/mol
 YesY (what is this?)  (verify)

Nizofenone (Ekonal, Midafenone) is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke.[1][2][3][4]


  1. ^ Ohta T, Kikuchi H, Hashi K, Kudo Y. Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study. Journal of Neurosurgery. 1986 Mar;64(3):420-6. PMID 3512795
  2. ^ Yasuda H, Izumi N, Nakanishi M, Maruyama Y. Brain protection against oxygen deficiency by nizofenone. Advances in Experimental Medicine and Biology. 1988;222:403-10. PMID 3364265
  3. ^ Yasuda H, Nakajima A. Brain protection against ischemic injury by nizofenone. Cerebrovascular and Brain Metabolism Reviews. 1993 Winter;5(4):264-76. PMID 8110594
  4. ^ Matsumoto Y, Aihara K, Kamata T, Goto N. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. European Journal of Pharmacology. 1994 Sep 1;262(1-2):157-61. PMID 7813567