The song was recorded for Streisand's Wet album and also as a new track for Summer's compilation double album entitled On the Radio: Greatest Hits Volumes 1 & 2. The full-length version was found on Streisand's album, while a longer 11 minute plus version (the 12" version) was featured on Summer's album. The Summer version features additional production by frequent collaborator Harold Faltermeyer, and incorporates a harder rock edge. The single was released on both Casablanca Records (Summer's label) and Columbia Records (Streisand's label) and sales of the two were amalgamated. The versions on the two 7" singles differed slightly however, with different mixes and slightly different background vocal arrangements. The formats differed between nations—in the UK for example, the song was only released on 7" by Casablanca, and 12" (the extended version from the On The Radio album) by Columbia.
Although the sales of the two labels' releases were amalgamated, both the 7" and the 12" were certified Gold by the RIAA in early 1980. The 7" single was eventually certified Platinum, signifying sales of two million US copies.
Bowing on the Hot 100 at number 59 on 20 October 1979, the single went to number one on the Billboard Hot 100 on 24 November – 1 December 1979 (making it both singers' fourth chart-topping single in the US, as well as Summer's final) and number one for four weeks on the disco chart. "No More Tears" was also a big international hit, and made the top three in both Canada and the UK.
Summer and Streisand never performed the song together live after recording it, although Summer did sing the song in concert with other female performers, including Tina Arena and her sister Mary Gaines Bernard.Barbra Streisand included a short snippet of it in her 2012 Back To Brooklyn Tour, talking about the recent passing of Donna Summer and how she wished Donna were alive to sing it with her. In 2017, a remix of the song with the title of "Enough Is Enough: 2017" climb to # 3 on the US Dance Club Songs chart.
"Enough is Enough" was part of the medley of songs about men that Liza Minnelli and her back-up girls (The Demon Divas) sang in 1993's "Liza Minnelli: Live from Radio City Music Hall."
Donna Summer performed a new version of the song with Tina Arena for a live concert which aired on VH-1 called Live & More Encore in 1999. The song was included on the album, as well as on Tina Arena's compilation album Souvenirs, released in Australia in 2000. Summer also performed another live version with Westlife on the British ITV's "Discomania" in 2004.