Non-stop decay

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Non-stop decay is a cellular mechanism of mRNA surveillance to detect mRNA molecules lacking a stop codon and prevent these mRNAs from translation. The non-stop decay pathway releases ribosomes that have reached the far 3' end of an mRNA and guides the mRNA to the exosome complex, or to RNase R in bacteria for selective degradation.[1][2] In contrast to NMD, polypeptides do not release from the ribosome, and thus, NSD seems to involve mRNA decay factors distinct from NMD.[3]

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  1. ^ Vasudevan; Peltz, SW; Wilusz, CJ; et al. (2002). "Non-stop decay--a new mRNA surveillance pathway". BioEssays. 24 (9): 785–8. PMID 12210514. doi:10.1002/bies.10153. 
  2. ^ Venkataraman, K; Guja, KE; Garcia-Diaz, M; Karzai, AW (2014). "Non-stop mRNA decay: a special attribute of trans-translation mediated ribosome rescue.". Frontiers in Microbiology. 5: 93. PMC 3949413Freely accessible. PMID 24653719. doi:10.3389/fmicb.2014.00093. 
  3. ^ Wu, X; Brewer, G (2012). "The regulation of mRNA stability in mammalian cells: 2.0.". Gene. 500: 10–21. PMC 3340483Freely accessible. PMID 22452843. doi:10.1016/j.gene.2012.03.021. 

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