Norethandrolone
 |
|
| Clinical data | |
|---|---|
| Trade names | Nilevar, Pronabol |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration |
Oral |
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
|
|
| Synonyms | Noretandrolone; CB-8022 |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ECHA InfoCard | 100.000.140 |
| Chemical and physical data | |
| Formula | C20H30O2 |
| Molar mass | 302.451 g/mol |
| 3D model (JSmol) | |
|
|
|
|
| (verify) | |
Norethandrolone (INN, BAN) (brand names Nilevar, Pronabol), also known as 17α-ethyl-19-nortestosterone or 17α-ethyl-19-norandrost-4-en-17β-ol-3-one, as well as ethylnandrolone or ethylnortestosterone, is a synthetic anabolic-androgenic steroid (AAS) and progestogen of the 17α-alkylated and 19-nortestosterone groups.[1] It was synthesized at G. D. Searle & Company in 1953 and was originally studied as a progestin, along with norethisterone and noretynodrel, but ultimately was not marketed as such.[2] In 1955, it was re-examined for testosterone-like activity and was found to have similar anabolic activity to testosterone but only one-sixteenth the androgenic potency.[2][3]
Norethandrolone was introduced in the United States as an AAS in 1965 under the trade name Nilevar[4] but was withdrawn from the market in the 1980s due to concerns of cholestatic jaundice.[3] Norethandrolone is now only marketed in Australia, France, and Switzerland, and as with all 17α-alkylated oral steroids, long-term use in high doses may result in elevated liver enzymes and consequently cirrhosis.[5] It is used in the treatment of muscle wasting,[3] patients with severe burns, after severe trauma, and for certain forms of aplastic anemia.
See also[edit]
References[edit]
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 885–. ISBN 978-1-4757-2085-3.
- ^ a b Charles D. Kochakian (6 December 2012). Anabolic-Androgenic Steroids. Springer Science & Business Media. pp. 380–. ISBN 978-3-642-66353-6.
- ^ a b c Walter Sneader (23 June 2005). Drug Discovery: A History. John Wiley & Sons. pp. 206–. ISBN 978-0-471-89979-2.
- ^ W., Llewellyn. (2005). Anabolics. p. 156.
- ^ D., Lednicer. (2011). Steroid Chemistry at Glance. Wiley. p. 67.
 |
This article about a steroid is a stub. You can help Wikipedia by expanding it. |
 |
This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it. |
