Norethandrolone

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Norethandrolone
Norethandrolone structure.png
Clinical data
Trade names Nilevar, Pronabol
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
ATC code A14AA09 (WHO)
Legal status
Legal status
Identifiers
Synonyms Noretandrolone; CB-8022
CAS Number 52-78-8 YesY
PubChem (CID) 5858
ChemSpider 5649 YesY
UNII P7W01638W6 YesY
KEGG D07127 YesY
ECHA InfoCard 100.000.140
Chemical and physical data
Formula C20H30O2
Molar mass 302.451 g/mol
3D model (Jmol) Interactive image
  (verify)

Norethandrolone (INN, BAN) (brand names Nilevar, Pronabol), also known as 17α-ethyl-19-nortestosterone or 17α-ethyl-19-norandrost-4-en-17β-ol-3-one, as well as ethylnandrolone or ethylnortestosterone, is a synthetic androgenic-anabolic steroid (AAS) and progestogen of the 17α-alkylated and 19-nortestosterone groups.[1] It was synthesized at G. D. Searle & Company in 1953 and was originally studied as a progestin, along with norethisterone and noretynodrel, but ultimately was not marketed as such.[2] In 1955, it was re-examined for testosterone-like activity and was found to have similar anabolic activity to testosterone but only one-sixteenth the androgenic potency.[2][3]

Norethandrolone was introduced in the United States as an AAS in 1965 under the trade name Nilevar[4] but was withdrawn from the market in the 1980s due to concerns of cholestatic jaundice.[3] Norethandrolone is now only marketed in Australia, France, and Switzerland, and as with all 17α-alkylated oral steroids, long-term use in high doses may result in elevated liver enzymes and consequently cirrhosis.[5] It is used in the treatment of muscle wasting,[3] patients with severe burns, after severe trauma, and for certain forms of aplastic anemia.

See also[edit]

References[edit]

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 885–. ISBN 978-1-4757-2085-3. 
  2. ^ a b Charles D. Kochakian (6 December 2012). Anabolic-Androgenic Steroids. Springer Science & Business Media. pp. 380–. ISBN 978-3-642-66353-6. 
  3. ^ a b c Walter Sneader (23 June 2005). Drug Discovery: A History. John Wiley & Sons. pp. 206–. ISBN 978-0-471-89979-2. 
  4. ^ W., Llewellyn. (2005). Anabolics. p. 156. 
  5. ^ D., Lednicer. (2011). Steroid Chemistry at Glance. Wiley. p. 67.