Nuclear mitotic apparatus protein 1

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Available structures
PDB Human UniProt search: PDBe RCSB
Aliases NUMA1, NUMA, NMP-22, nuclear mitotic apparatus protein 1
External IDs MGI: 2443665 HomoloGene: 38150 GeneCards: NUMA1
RNA expression pattern
PBB GE NUMA1 214251 s at fs.png

PBB GE NUMA1 200747 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 72 – 72.08 Mb Chr 7: 101.93 – 102.01 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.[3][4]


Nuclear mitotic apparatus protein 1 has been shown to interact with PIM1,[5] Band 4.1,[6] GPSM2[7] and EPB41L1.[8]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Sparks CA, Bangs PL, McNeil GP, Lawrence JB, Fey EG (Oct 1993). "Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13". Genomics. 17 (1): 222–224. doi:10.1006/geno.1993.1307. PMID 8406455. 
  4. ^ "Entrez Gene: NUMA1 nuclear mitotic apparatus protein 1". 
  5. ^ Bhattacharya, Nandini; Wang Zeping; Davitt Christine; McKenzie Ian F C; Xing Pei-Xiang; Magnuson Nancy S (Jul 2002). "Pim-1 associates with protein complexes necessary for mitosis". Chromosoma. Germany. 111 (2): 80–95. doi:10.1007/s00412-002-0192-6. ISSN 0009-5915. PMID 12111331. 
  6. ^ Mattagajasingh, S N; Huang S C; Hartenstein J S; Snyder M; Marchesi V T; Benz E J (Apr 1999). "A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein". J. Cell Biol. UNITED STATES. 145 (1): 29–43. doi:10.1083/jcb.145.1.29. ISSN 0021-9525. PMC 2148212Freely accessible. PMID 10189366. 
  7. ^ Du, Q; Stukenberg P T; Macara I G (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. England. 3 (12): 1069–1075. doi:10.1038/ncb1201-1069. ISSN 1465-7392. PMID 11781568. 
  8. ^ Ye, K; Compton D A; Lai M M; Walensky L D; Snyder S H (Dec 1999). "Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor". J. Neurosci. UNITED STATES. 19 (24): 10747–56. PMID 10594058. 

Further reading[edit]