Nucleolar protein, member A1

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GAR1
Identifiers
Aliases GAR1, NOLA1, Nucleolar protein, member A1, GAR1 ribonucleoprotein
External IDs HomoloGene: 137420 GeneCards: GAR1
RNA expression pattern
PBB GE NOLA1 219110 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032993
NM_018983

n/a

RefSeq (protein)

NP_061856
NP_127460

n/a

Location (UCSC) Chr 4: 109.82 – 109.82 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

H/ACA ribonucleoprotein complex subunit 1 is a protein that in humans is encoded by the GAR1 gene.[2][3]

Function[edit]

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.[3]

Interactions[edit]

Nucleolar protein, member A1 has been shown to interact with SMN1.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Dragon F, Pogacić V, Filipowicz W (May 2000). "In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs". Mol Cell Biol. 20 (9): 3037–48. doi:10.1128/MCB.20.9.3037-3048.2000. PMC 85579Freely accessible. PMID 10757788. 
  3. ^ a b "Entrez Gene: NOLA1 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)". 
  4. ^ Pellizzoni L, Baccon J, Charroux B, Dreyfuss G (Jul 2001). "The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1". Curr. Biol. 11 (14): 1079–88. doi:10.1016/S0960-9822(01)00316-5. PMID 11509230. 

Further reading[edit]