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Nullification may refer to:
- Nullification (U.S. Constitution), the legal principle that any federal enactment which is not "made in Pursuance" of the Constitution under Article VI, Clause 2 is ipso facto null and void.
- Nullification Crisis, the 1832 confrontation between the U.S. government and South Carolina over the latter's attempt to nullify a federal law
- Jury nullification, a legal term for a jury's ability to deliver a verdict knowingly in contradiction to written law
- Nullification, a form of body modification involving the voluntary removal of body parts
- U.S. Constitution, Article VI, Clause 2; Marbury v. Madison, 5 U.S. 137 (1803); Ex parte Siebold, 100 U.S. 371 (1879)
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