|Chemical and physical data|
|Molar mass||417.56 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
O-2050 is a drug that is a classical cannabinoid derivative, which acts as an antagonist for the CB1 receptor. This gives it an advantage in research over many commonly used cannabinoid antagonists, such as rimonabant, which at higher doses act as inverse agonists at CB1 as well as showing off-target effects. However, while O-2050 acts as a silent antagonist in vitro, some tests in vivo have suggested it may show agonist activity under certain circumstances.
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- ^ US 7279500, Martin, Billy R.; Razdan, Raj K. & Pertwee, Roger G, "Sulfonamide cannabinoid agonists and antagonists", published 2007-10-09, assigned to Virginia Commonwealth University
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- ^ Higuchi S, Irie K, Mishima S, Araki M, Ohji M, Shirakawa A, et al. (2010). "The cannabinoid 1-receptor silent antagonist O-2050 attenuates preference for high-fat diet and activated astrocytes in mice". Journal of Pharmacological Sciences. 112 (3): 369–72. doi:10.1254/jphs.09326sc. PMID 20168044.
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- ^ Wiley JL, Breivogel CS, Mahadevan A, Pertwee RG, Cascio MG, Bolognini D, et al. (January 2011). "Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist". European Journal of Pharmacology. 651 (1–3): 96–105. doi:10.1016/j.ejphar.2010.10.085. PMC 3034309. PMID 21114999.