O-2694 is a drug that is a cannabinoid derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both CB1 and CB2receptors, with Ki values of 3.7 nM at CB1 and 2.8 nM at CB2. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the ester link to the water-insoluble compound O-2372, thus producing a biphasic effects profile that is less suitable for research purposes than the related compound O-2545.
^Martin, B. R.; Wiley, J. L.; Beletskaya, I; Sim-Selley, L. J.; Smith, F. L.; Dewey, W. L.; Cottney, J; Adams, J; Baker, J; Hill, D; Saha, B; Zerkowski, J; Mahadevan, A; Razdan, R. K. (2006). "Pharmacological characterization of novel water-soluble cannabinoids". Journal of Pharmacology and Experimental Therapeutics. 318 (3): 1230–9. PMID16757541. doi:10.1124/jpet.106.104109.