O-2694

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O-2694
O-2694.png
Systematic (IUPAC) name
(6aR,10aR)-6,6,9-trimethyl-3-(2-methyl-7-morpholin-4-yl-7-oxoheptan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-yl 4-(di(propan-2-yl)amino)butanoate
Identifiers
PubChem CID 11714280
ChemSpider 9889001 N
Chemical data
Formula C38H60N2O5
Molar mass 624.891 g/mol
 NYesY (what is this?)  (verify)

O-2694 is a drug that is a cannabinoid derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both CB1 and CB2 receptors, with Ki values of 3.7 nM at CB1 and 2.8 nM at CB2. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the ester link to the water-insoluble compound O-2372, thus producing a biphasic effects profile that is less suitable for research purposes than the related compound O-2545.[1]

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References[edit]

  1. ^ Martin, B. R.; Wiley, J. L.; Beletskaya, I; Sim-Selley, L. J.; Smith, F. L.; Dewey, W. L.; Cottney, J; Adams, J; Baker, J; Hill, D; Saha, B; Zerkowski, J; Mahadevan, A; Razdan, R. K. (2006). "Pharmacological characterization of novel water-soluble cannabinoids". Journal of Pharmacology and Experimental Therapeutics. 318 (3): 1230–9. doi:10.1124/jpet.106.104109. PMID 16757541.