OAS1

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OAS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOAS1, IFI-4, OIAS, OIASI, E18/E16, 2'-5'-oligoadenylate synthetase 1
External IDsMGI: 2180860 HomoloGene: 1903 GeneCards: OAS1
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for OAS1
Genomic location for OAS1
Band12q24.13Start112,906,777 bp[1]
End112,933,222 bp[1]
RNA expression pattern
PBB GE OAS1 205552 s at fs.png

PBB GE OAS1 202869 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001032409
NM_002534
NM_016816
NM_001320151

NM_145211

RefSeq (protein)

NP_001027581
NP_001307080
NP_002525
NP_058132

NP_660212

Location (UCSC)Chr 12: 112.91 – 112.93 MbChr 5: 120.9 – 120.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.[5][6]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in both viral and endogenous RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089127 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052776 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, Monk S, Carter S, Ross CJ, Pang J, Twells R, Chamberlain S, Monaco AP, Strachan T, Kucherlapati R (Feb 1998). "A sequence-ready physical map of a region of 12q24.1". Genomics. 45 (2): 271–8. doi:10.1006/geno.1997.4888. PMID 9344649. 
  6. ^ Nechiporuk T, Nechiporuk A, Sahba S, Figueroa K, Shibata H, Chen XN, Korenberg JR, de Jong P, Pulst SM (Nov 1997). "A high-resolution PAC and BAC map of the SCA2 region". Genomics. 44 (3): 321–9. doi:10.1006/geno.1997.4886. PMID 9325053. 
  7. ^ "Entrez Gene: OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa". 

Further reading[edit]