OAS2

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OAS2
Identifiers
Aliases OAS2, 2'-5'-oligoadenylate synthetase 2
External IDs MGI: 2180852 HomoloGene: 49478 GeneCards: OAS2
RNA expression pattern
PBB GE OAS2 204972 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001032731
NM_002535
NM_016817

NM_145227
NM_001347448

RefSeq (protein)

NP_001027903
NP_002526
NP_058197

NP_660262.2
NP_001334377
NP_660262

Location (UCSC) Chr 12: 112.98 – 113.01 Mb Chr 5: 120.73 – 120.75 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene.[3][4]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–277. doi:10.1006/geno.1998.5443. PMID 9790745. 
  4. ^ a b "Entrez Gene: OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa". 

Further reading[edit]