OAS3

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OAS3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases OAS3, p100, p100OAS, 2'-5'-oligoadenylate synthetase 3
External IDs MGI: 2180850 HomoloGene: 4510 GeneCards: OAS3
RNA expression pattern
PBB GE OAS3 218400 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006187

NM_145226

RefSeq (protein)

NP_006178

NP_660261.1
NP_660261

Location (UCSC) Chr 12: 112.94 – 112.97 Mb Chr 5: 120.75 – 120.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.[3][4]

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligos activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745. 
  4. ^ a b "Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa". 

Further reading[edit]