From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases ODF2, CT134, ODF2/1, ODF2/2, ODF84, outer dense fiber of sperm tails 2
External IDs MGI: 1098824 HomoloGene: 1907 GeneCards: ODF2
RNA expression pattern
PBB GE ODF2 210415 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC) Chr 9: 128.46 – 128.5 Mb Chr 2: 29.89 – 29.93 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Outer dense fiber protein 2, also known as cenexin, is a protein that in humans is encoded by the ODF2 gene.[3][4][5]

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of this gene; however, not all isoforms and variants have been fully described.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Shao X, Tarnasky HA, Schalles U, Oko R, van der Hoorn FA (Apr 1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27". J Biol Chem. 272 (10): 6105–13. doi:10.1074/jbc.272.10.6105. PMID 9045620. 
  4. ^ Shao X, Murthy S, Demetrick DJ, van der Hoorn FA (Mar 1999). "Human outer dense fiber gene, ODF2, localizes to chromosome 9q34". Cytogenet Cell Genet. 83 (3–4): 221–3. doi:10.1159/000015183. PMID 10072582. 
  5. ^ a b "Entrez Gene: ODF2 outer dense fiber of sperm tails 2". 

Further reading[edit]