OGN (gene)

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OGN
Identifiers
Aliases OGN, OG, OIF, SLRR3A, osteoglycin
External IDs MGI: 109278 HomoloGene: 8542 GeneCards: OGN
RNA expression pattern
PBB GE OGN 218730 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033014
NM_014057
NM_024416

NM_008760

RefSeq (protein)

NP_054776
NP_077727
NP_148935
NP_054776.1
NP_148935.1

NP_032786.1
NP_032786

Location (UCSC) Chr 9: 92.38 – 92.4 Mb Chr 13: 49.61 – 49.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.[3]

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.[3]

The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.[4][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: OGN osteoglycin". 
  4. ^ "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. Retrieved 2008-06-07. 
  5. ^ Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC 2742198Freely accessible. PMID 18443592. 

Further reading[edit]