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Aliases OPCML, IGLON1, OBCAM, OPCM, opioid binding protein/cell adhesion molecule-like, opioid binding protein/cell adhesion molecule like
External IDs MGI: 97397 HomoloGene: 55663 GeneCards: OPCML
Genetically Related Diseases
Alcohol dependence[1]
RNA expression pattern
PBB GE OPCML 206215 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 11: 132.41 – 133.53 Mb Chr 9: 27.79 – 28.93 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.[4][5]

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.[5]


  1. ^ "Diseases that are genetically associated with OPCML view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics. 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID 8244387. 
  5. ^ a b "Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like". 

Further reading[edit]