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Opsin 3
Symbols OPN3 ; ECPN; PPP1R116
External IDs OMIM606695 MGI1338022 HomoloGene40707 IUPHAR: 160 GeneCards: OPN3 Gene
RNA expression pattern
PBB GE OPN3 219032 x at tn.png
More reference expression data
Species Human Mouse
Entrez 23596 13603
Ensembl ENSG00000054277 ENSMUSG00000026525
UniProt Q9H1Y3 Q9WUK7
RefSeq (mRNA) NM_001030011 NM_010098
RefSeq (protein) NP_055137 NP_034228
Location (UCSC) Chr 1:
241.59 – 241.68 Mb
Chr 1:
175.66 – 175.69 Mb
PubMed search [1] [2]

Opsin-3 also known as encephalopsin or panopsin[1] is a protein that, in humans, is encoded by the OPN3 gene.[2][3][4] Alternative splicing of this gene results in multiple transcript variants encoding different protein isoforms.[5]


Opsins are members of the G protein-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in tissues outside the eye. The opsin-3 gene is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene is expressed in the skin[5] and may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein.[4]


  1. ^ Koyanagi M, Takada E, Nagata T, Tsukamoto H, Terakita A (Mar 2013). "Homologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue". Proceedings of the National Academy of Sciences of the United States of America 110 (13): 4998–5003. doi:10.1073/pnas.1219416110. PMID 23479626. 
  2. ^ Blackshaw S, Snyder SH (May 1999). "Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain". The Journal of Neuroscience 19 (10): 3681–90. PMID 10234000. 
  3. ^ Halford S, Freedman MS, Bellingham J, Inglis SL, Poopalasundaram S, Soni BG, Foster RG, Hunt DM (Mar 2001). "Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43". Genomics 72 (2): 203–8. doi:10.1006/geno.2001.6469. PMID 11401433. 
  4. ^ a b "Entrez Gene: OPN3 opsin 3 (encephalopsin, panopsin)". 
  5. ^ a b Haltaufderhyde K, Ozdeslik RN, Wicks NL, Najera JA, Oancea E (January 2015). "Opsin expression in human epidermal skin". Photochemistry and Photobiology 91 (1): 117–23. doi:10.1111/php.12354. PMID 25267311. 

Further reading[edit]

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Halford S, Bellingham J, Ocaka L, Fox M, Johnson S, Foster RG, Hunt DM (2002). "Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids". Cytogenetics and Cell Genetics 95 (3-4): 234–5. doi:10.1159/000059351. PMID 12063405. 
  • Kasper G, Taudien S, Staub E, Mennerich D, Rieder M, Hinzmann B, Dahl E, Schwidetzky U, Rosenthal A, Rump A (Jul 2002). "Different structural organization of the encephalopsin gene in man and mouse". Gene 295 (1): 27–32. doi:10.1016/S0378-1119(02)00799-0. PMID 12242008. 
  • Alam NA, Gorman P, Jaeger EE, Kelsell D, Leigh IM, Ratnavel R, Murdoch ME, Houlston RS, Aaltonen LA, Roylance RR, Tomlinson IP (Dec 2003). "Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability". Cancer Genetics and Cytogenetics 147 (2): 121–7. doi:10.1016/S0165-4608(03)00196-1. PMID 14623461. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.