Opticin

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OPTC
Identifiers
Aliases OPTC, OPT, opticin
External IDs MGI: 2151113 HomoloGene: 8652 GeneCards: OPTC
RNA expression pattern
PBB GE OPTC gnf1h00162 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014359

NM_001160420
NM_001160421
NM_001160422
NM_054076

RefSeq (protein)

NP_055174

NP_473417.2
NP_001153892
NP_001153893
NP_001153894
NP_473417

Location (UCSC) Chr 1: 203.49 – 203.51 Mb Chr 1: 133.9 – 133.91 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Opticin is a protein that in humans is encoded by the OPTC gene.[3][4]

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN (Feb 2000). "Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix". J Biol Chem. 275 (3): 2123–9. doi:10.1074/jbc.275.3.2123. PMID 10636917. 
  4. ^ a b "Entrez Gene: OPTC opticin". 

Further reading[edit]