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Aliases OR4F4, OLA-7501, OR4F18, olfactory receptor family 4 subfamily F member 4
External IDs HomoloGene: 128250 GeneCards: OR4F4
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for OR4F4
Genomic location for OR4F4
Band n/a Start 101,922,042 bp[1]
End 101,923,095 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 101.92 – 101.92 Mb n/a
PubMed search [2] n/a
View/Edit Human

Olfactory receptor 4F4 is a protein that in humans is encoded by the OR4F4 gene.[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also[edit]


Further reading[edit]

  • Trask BJ, Friedman C, Martin-Gallardo A, et al. (1998). "Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes.". Hum. Mol. Genet. 7 (1): 13–26. PMID 9384599. doi:10.1093/hmg/7.1.13. 
  • Mefford HC, Linardopoulou E, Coil D, et al. (2002). "Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.". Hum. Mol. Genet. 10 (21): 2363–72. PMID 11689483. doi:10.1093/hmg/10.21.2363. 
  • Linardopoulou E, Mefford HC, Nguyen O, et al. (2002). "Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.". Hum. Mol. Genet. 10 (21): 2373–83. PMID 11689484. doi:10.1093/hmg/10.21.2373. 
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics. 80 (3): 295–302. PMID 12213199. doi:10.1006/geno.2002.6830. 
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. PMC 356993Freely accessible. PMID 14983052. doi:10.1073/pnas.0307882100. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.