OR6A2

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Olfactory receptor, family 6, subfamily A, member 2
Identifiers
Symbols OR6A2 ; I7; OR11-55; OR6A1; OR6A2P
External IDs OMIM608495 MGI97432 HomoloGene2743 GeneCards: OR6A2 Gene
RNA expression pattern
PBB GE OR6A2 221465 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8590 18317
Ensembl ENSG00000184933 ENSMUSG00000070417
UniProt O95222 Q80WD6
RefSeq (mRNA) NM_003696 NM_010983
RefSeq (protein) NP_003687 NP_035113
Location (UCSC) Chr 11:
6.82 – 6.82 Mb
Chr 7:
107 – 107 Mb
PubMed search [1] [2]

Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene.[1]

Function[edit]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

Clinical significance[edit]

Variation in the OR6A2 gene has been identified as a likely cause of some people's strong dislike of cilantro (also known as coriander).[2]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2". 
  2. ^ Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi:10.1038/nature.2012.11398. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.