OR6A2

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OR6A2
Identifiers
AliasesOR6A2, I7, OR11-55, OR6A1, OR6A2P, olfactory receptor family 6 subfamily A member 2
External IDsMGI: 97432 HomoloGene: 2743 GeneCards: OR6A2
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR6A2
Genomic location for OR6A2
Band11p15.4Start6,791,736 bp[1]
End6,799,689 bp[1]
RNA expression pattern
PBB GE OR6A2 221465 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003696

NM_010983

RefSeq (protein)

NP_003687

n/a

Location (UCSC)Chr 11: 6.79 – 6.8 MbChr 7: 107 – 107.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene.[5]

Function[edit]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Clinical significance[edit]

Variation in the OR6A2 gene has been identified as a likely cause of some people's strong dislike of coriander (also known as cilantro)[6], often associating it with a combination of soap and vomit, while for others it is closer to the foul smelling odor emitted by stinkbugs. This is due to the presence of aldehyde chemicals, which are present in soap, various detergents, coriander, several species of stinkbugs and cinnamon.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184933 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070417 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2".
  6. ^ Eriksson N, Wu S, Chuong BD, et al. (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. doi:10.1186/2044-7248-1-22.
  7. ^ Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi:10.1038/nature.2012.11398.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.