OR7D4

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OR7D4
Identifiers
AliasesOR7D4, OR19-7, OR19-B, OR19B, OR7D4P, hg105, olfactory receptor family 7 subfamily D member 4
External IDsMGI: 1313142 HomoloGene: 81583 GeneCards: OR7D4
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for OR7D4
Genomic location for OR7D4
Band19p13.2Start9,210,276 bp[1]
End9,219,589 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005191

NM_146825

RefSeq (protein)

NP_001005191

n/a

Location (UCSC)Chr 19: 9.21 – 9.22 MbChr 9: 20.28 – 20.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 7D4 is a protein that in humans is encoded by the OR7D4 gene.[5][6][7][8][9][10][11]

Function[edit]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174667 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059623 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: OR7D4 olfactory receptor, family 7, subfamily D, member 4". Retrieved 2013-12-17. 
  6. ^ Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199. 
  7. ^ Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993Freely accessible. PMID 14983052. 
  8. ^ Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H (September 2007). "Genetic variation in a human odorant receptor alters odour perception". Nature. 449 (7161): 468–72. doi:10.1038/nature06162. PMID 17873857. 
  9. ^ OR7D4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
  10. ^ Lunde K, Egelandsdal B, Skuterud E, Mainland JD, Lea T, Hersleth M, Matsunami H (2012). Behrens M, ed. "Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone". PLOS One. 7 (5): e35259. doi:10.1371/journal.pone.0035259. PMC 3342276Freely accessible. PMID 22567099. 
  11. ^ Wysocki CJ, Beauchamp GK (August 1984). "Ability to smell androstenone is genetically determined". Proceedings of the National Academy of Sciences of the United States of America. 81 (15): 4899–902. doi:10.1073/pnas.81.15.4899. PMC 391599Freely accessible. PMID 6589634. 
  12. ^ Hornung J, Noack H, Thomas M, Farger G, Nieratschker V, Freiherr J, Derntl B (February 2018). "Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction". Hormones and Behavior. 98: 45–54. doi:10.1016/j.yhbeh.2017.12.003. PMID 29246659. 
  13. ^ de March CA, Topin J, Bruguera E, Novikov G, Ikegami K, Matsunami H, Golebiowski J (April 2018). "Odorant Receptor 7D4 Activation Dynamics". Angewandte Chemie. 57 (17): 4554–4558. doi:10.1002/anie.201713065. PMID 29462498. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.