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Aliases ORC4, ORC4L, ORC4P, origin recognition complex subunit 4
External IDs MGI: 1347043 HomoloGene: 8059 GeneCards: ORC4
RNA expression pattern
PBB GE ORC4L 203351 s at fs.png

PBB GE ORC4L 203352 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 2: 147.93 – 148.02 Mb Chr 2: 48.9 – 48.95 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.[3][4][5]


The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.[5]


ORC4 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. PMID 9353276. doi:10.1074/jbc.272.45.28247. 
  4. ^ Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22-->q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. PMID 9691185. doi:10.1159/000014997. 
  5. ^ a b "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)". 
  6. ^ a b c d e f g h Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. PMID 12614612. doi:10.1016/s0022-2836(03)00079-2. 
  7. ^ a b c Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. PMID 11395502. doi:10.1074/jbc.M103078200. 
  8. ^ a b Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. PMID 11323433. doi:10.1074/jbc.M102493200. 
  9. ^ Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. PMID 10402192. doi:10.1016/s0896-6273(00)80752-7. 
  10. ^ Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. PMID 9765232. doi:10.1074/jbc.273.42.27137. 

Further reading[edit]