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Available structures
PDB Human UniProt search: PDBe RCSB
Aliases ORM1, AGP-A, AGP1, HEL-S-153w, ORM, orosomucoid 1
External IDs HomoloGene: 128040 GeneCards: ORM1
RNA expression pattern
PBB GE ORM1 214465 at fs.png

PBB GE ORM1 205040 at fs.png

PBB GE ORM1 205041 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 114.32 – 114.33 Mb n/a
PubMed search [1] n/a
View/Edit Human

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.[2]

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.[2]


ORM1 has been shown to interact with Plasminogen activator inhibitor-1.[3]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ a b "Entrez Gene: ORM1 orosomucoid 1". 
  3. ^ Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity". J. Biol. Chem. United States. 276 (38): 35305–11. doi:10.1074/jbc.M104028200. ISSN 0021-9258. PMID 11418606. 

Further reading[edit]

  • Treuheit MJ, Costello CE, Halsall HB (1992). "Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.". Biochem. J. 283 (1): 105–12. PMC 1131000Freely accessible. PMID 1567356. 
  • Dente L, Ciliberto G, Cortese R (1985). "Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.". Nucleic Acids Res. 13 (11): 3941–52. doi:10.1093/nar/13.11.3941. PMC 341288Freely accessible. PMID 2409529. 
  • Dubé JY, Paradis G, Têtu B, Tremblay RR (1989). "Synthesis of alpha 1-acid glycoprotein by the human prostate.". Prostate. 15 (3): 251–8. doi:10.1002/pros.2990150305. PMID 2479939. 
  • Zuffardi O, Caiulo A, Maraschio P, et al. (1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?". Hum. Genet. 82 (1): 17–9. doi:10.1007/bf00288264. PMID 2541064. 
  • Dente L, Pizza MG, Metspalu A, Cortese R (1987). "Structure and expression of the genes coding for human alpha 1-acid glycoprotein.". EMBO J. 6 (8): 2289–96. PMC 553631Freely accessible. PMID 2822385. 
  • Merritt CM, Board PG (1988). "Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene.". Gene. 66 (1): 97–106. doi:10.1016/0378-1119(88)90228-4. PMID 2970990. 
  • Dente L, Rüther U, Tripodi M, et al. (1988). "Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice.". Genes Dev. 2 (2): 259–66. doi:10.1101/gad.2.2.259. PMID 3360326. 
  • Rocchi M, Roncuzzi L, Santamaria R, et al. (1986). "Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9.". Hum. Genet. 74 (1): 30–3. doi:10.1007/BF00278781. PMID 3463531. 
  • Board PG, Jones IM, Bentley AK (1986). "Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.". Gene. 44 (1): 127–31. doi:10.1016/0378-1119(86)90051-X. PMID 3770479. 
  • Krauss E, Polnaszek CF, Scheeler DA, et al. (1987). "Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera.". J. Pharmacol. Exp. Ther. 239 (3): 754–9. PMID 3795040. 
  • Ikenaka T, Ishiguro M, Emura J, et al. (1972). "Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.". Biochemistry. 11 (20): 3817–29. doi:10.1021/bi00770a022. PMID 4561179. 
  • Schmid K, Bürgi W, Collins JH, Nanno S (1974). "The disulfide bonds of alpha1-acid glycoprotein.". Biochemistry. 13 (13): 2694–7. doi:10.1021/bi00710a006. PMID 4603214. 
  • Schmid K, Kaufmann H, Isemura S, et al. (1973). "Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.". Biochemistry. 12 (14): 2711–24. doi:10.1021/bi00738a026. PMID 4711474. 
  • Mbuyi JM, Dequeker J, Bloemmen F, Stevens E (1982). "Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE.". Calcif. Tissue Int. 34 (3): 229–31. doi:10.1007/BF02411242. PMID 6809283. 
  • Rabehi L, Ferriere F, Saffar L, Gattegno L (1995). "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans.". Glycoconj. J. 12 (1): 7–16. doi:10.1007/BF00731863. PMID 7795416. 
  • Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819. 
  • Nakamura T, Board PG, Matsushita K, et al. (1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis.". Inflammation. 17 (1): 33–45. doi:10.1007/BF00916390. PMID 8432561. 
  • Yuasa I, Umetsu K, Vogt U, et al. (1997). "Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.". Hum. Genet. 99 (3): 393–8. doi:10.1007/s004390050378. PMID 9050929. 
  • Morin D, Simon N, Deprés-Brummer P, et al. (1997). "Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum.". Pharmacology. 54 (5): 271–5. doi:10.1159/000139495. PMID 9380773. 
  • Nakamura H, Yuasa I, Umetsu K, et al. (2000). "The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2.". Biochem. Biophys. Res. Commun. 276 (2): 779–84. doi:10.1006/bbrc.2000.3522. PMID 11027547.