OSBP2

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OSBP2
Identifiers
Aliases OSBP2, HLM, ORP-4, ORP4, OSBPL1, OSBPL4, oxysterol binding protein 2
External IDs MGI: 1921559 HomoloGene: 75303 GeneCards: OSBP2
RNA expression pattern
PBB GE OSBP2 221237 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152818
NM_001302630
NM_001302631

RefSeq (protein)

NP_690031.2
NP_001289559
NP_001289560
NP_690031

Location (UCSC) Chr 22: 30.69 – 30.91 Mb Chr 11: 3.7 – 3.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.[3][4][5][6]

Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  4. ^ Moreira EF, Jaworski C, Li A, Rodriguez IR (May 2001). "Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina". J Biol Chem. 276 (21): 18570–8. doi:10.1074/jbc.M011259200. PMID 11278871. 
  5. ^ Wang C, JeBailey L, Ridgway ND (Jan 2002). "Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments". Biochem J. 361 (Pt 3): 461–72. doi:10.1042/0264-6021:3610461. PMC 1222328Freely accessible. PMID 11802775. 
  6. ^ a b "Entrez Gene: OSBP2 oxysterol binding protein 2". 

Further reading[edit]