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OSC may refer to:
- Odborové sdružení československé, the Czechoslovak Trade Union Association
- Office of Special Counsel (in the United States of America)
- Ohio Supercomputer Center, a computing research facility in Columbus
- Ontario Science Centre, a science museum in Toronto, Canada
- Ontario Securities Commission, a securities regulatory agency
- Open Source Center, a United States government center that provides analysis of open-source intelligence
- Open Source Consortium, The UK Open Source trade association
- Orbital Sciences Corporation, a satellite-oriented company
- Order of Saint Clare, a Religious Order founded by Clare of Assisi whose members use the post-nominal letters O.S.C.
- Ordo Sanctae Crucis or Canons Regular of the Order of the Holy Cross, a Roman Catholic religious order commonly called Crosiers
- Orlando Science Center, a science-education establishment in Florida
- Overseas School of Colombo, a multinational English medium international school located in Colombo, Sri Lanka.
- Open Sound Control, a music-oriented electronic communications protocol used in computers and multimedia devices
- openSUSE Command-line tool, a command-line tool used for openSUSE build service
- Operating system command, one of the C0 and C1 control codes
- Optical Signature Code, an industry standard format for LWIR signatures.
- Off-site construction, a mode of construction
- Osceola (Amtrak station), Iowa, United States; Amtrak station code OSC
- Orson Scott Card, author of speculative fiction
- Organic solar cell
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