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OTG may refer to:

  • OTG (n-octyl beta-D-thioglucopyranoside), a detergent
  • USB On-The-Go, a communications standard for portable devices
  • Off-the-grid, a lifestyle without access to public utilities
  • One-Two-GO Airlines (ICAO code), a defunct Thai air carrier
  • Over The Glasses, a goggle type, usually ski goggle, that fits over glasses (spectacles)
  • Outside The Gates, a term used in some military circles to refer to personnel, areas, locations, or goods outside the physical boundaries of a base or headquarters
  • An appliance having functions of Oven, Toast and Grill
  • OpenTerrainGenerator, a user-made modification for the game Minecraft, which lets users generate diverse terrain.