This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear. A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.
Weimann JM, Zhang YA, Levin ME, et al. (2000). "Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets". Neuron24 (4): 819–31. doi:10.1016/S0896-6273(00)81030-2. PMID10624946.
Francks C, Fisher SE, Olson RK, et al. (2002). "Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1". Psychiatr. Genet.12 (1): 35–41. doi:10.1097/00041444-200203000-00005. PMID11901358.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Puelles E, Annino A, Tuorto F, et al. (2004). "Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain". Development131 (9): 2037–48. doi:10.1242/dev.01107. PMID15105370.