OTX1

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OTX1
Identifiers
Aliases OTX1
External IDs MGI: 97450 HomoloGene: 7875 GeneCards: 5013
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199770
NM_014562

NM_011023

RefSeq (protein)

NP_001186699.1
NP_055377.1

NP_035153.1

Location (UCSC) Chr 2: 63.05 – 63.06 Mb Chr 11: 21.99 – 22 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.[3][4]

Function[edit]

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear.[5] A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (July 1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790. 
  4. ^ a b "Entrez Gene: OTX1 orthodenticle homeobox 1". 
  5. ^ Shubin, Neil "Your Inner Fish" 2009

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.