OVGP1

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OVGP1
Identifiers
Aliases OVGP1, CHIT5, EGP, MUC9, OGP, oviductal glycoprotein 1
External IDs MGI: 106661 HomoloGene: 74442 GeneCards: OVGP1
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OVGP1
Genomic location for OVGP1
Band 1p13.2 Start 111,414,314 bp[1]
End 111,427,777 bp[1]
RNA expression pattern
PBB GE OVGP1 205432 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002557

NM_007696

RefSeq (protein)

NP_002548

NP_031722

Location (UCSC) Chr 1: 111.41 – 111.43 Mb Chr 1: 105.97 – 105.99 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein (EGP) or mucin-9 (MUC9) is a protein that in humans is encoded by the OVGP1 gene.[5][6][7]

Function[edit]

Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoon acrosomal regions.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000085465 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074340 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod. 51 (4): 685–94. doi:10.1095/biolreprod51.4.685. PMID 7819450. 
  6. ^ Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril. 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614. 
  7. ^ a b "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)". 

Further reading[edit]