OX40 ligand

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tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)
Symbol TNFSF4
Alt. symbols TXGP1, OX-40L, gp34, CD252
Entrez 7292
HUGO 11934
OMIM 603594
RefSeq NM_003326
UniProt P23510
Other data
Locus Chr. 1 q25

OX40L is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.[1] OX40L has also been designated CD252 (cluster of differentiation 252).

Various single nucleotide polymorphisms (SNPs) of the OX40L gene have been identified. For some of them association with systemic lupus erythematosus has been reported:[2] No association with occurrence of atherosclerosis has been found.[3]


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