OXGR1

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Oxoglutarate (alpha-ketoglutarate) receptor 1
Identifiers
Symbols OXGR1 ; GPR80; GPR99; P2RY15; P2Y15; aKGR
External IDs OMIM606922 MGI2685145 HomoloGene25878 IUPHAR: 162 GeneCards: OXGR1 Gene
RNA expression pattern
PBB GE OXGR1 gnf1h10308 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27199 239283
Ensembl ENSG00000165621 ENSMUSG00000044819
UniProt Q96P68 Q6IYF8
RefSeq (mRNA) NM_080818 NM_001001490
RefSeq (protein) NP_543008 NP_001001490
Location (UCSC) Chr 13:
96.99 – 96.99 Mb
Chr 14:
120.02 – 120.04 Mb
PubMed search [1] [2]

2-Oxoglutarate receptor 1 (OXGR1), also known as cysteinyl leukotriene receptor E (CysLTE) and GPR99,[1] is a protein that in humans is encoded by the OXGR1 gene.[2][3][4]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[4]

References[edit]

  1. ^ Kanaoka Y, Maekawa A, Austen KF (Apr 2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". The Journal of Biological Chemistry 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866. PMID 23504326. 
  2. ^ He W, Miao FJ, Lin DC, Schwandner RT, Wang Z, Gao J, Chen JL, Tian H, Ling L (May 2004). "Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors". Nature 429 (6988): 188–93. doi:10.1038/nature02488. PMID 15141213. 
  3. ^ Wittenberger T, Hellebrand S, Munck A, Kreienkamp HJ, Schaller HC, Hampe W (Jul 2002). "GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors". BMC Genomics 3: 17. doi:10.1186/1471-2164-3-17. PMC 117779. PMID 12098360. 
  4. ^ a b "Entrez Gene: OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1". 

Further reading[edit]

  • Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Inbe H, Watanabe S, Miyawaki M, Tanabe E, Encinas JA (May 2004). "Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine". The Journal of Biological Chemistry 279 (19): 19790–9. doi:10.1074/jbc.M400360200. PMID 15001573. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.