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Oxoglutarate (alpha-ketoglutarate) receptor 1
Symbols OXGR1 ; GPR80; GPR99; P2RY15; P2Y15; aKGR
External IDs OMIM606922 MGI2685145 HomoloGene25878 IUPHAR: 162 GeneCards: OXGR1 Gene
RNA expression pattern
PBB GE OXGR1 gnf1h10308 at fs.png
More reference expression data
Species Human Mouse
Entrez 27199 239283
Ensembl ENSG00000165621 ENSMUSG00000044819
UniProt Q96P68 Q6IYF8
RefSeq (mRNA) NM_080818 NM_001001490
RefSeq (protein) NP_543008 NP_001001490
Location (UCSC) Chr 13:
96.99 – 96.99 Mb
Chr 14:
120.02 – 120.04 Mb
PubMed search [1] [2]

2-Oxoglutarate receptor 1 (OXGR1), also known as cysteinyl leukotriene receptor E (CysLTE) and GPR99,[1] is a protein that in humans is encoded by the OXGR1 gene.[2][3][4]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[4]


  1. ^ Kanaoka Y, Maekawa A, Austen KF (Apr 2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". The Journal of Biological Chemistry 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866. PMID 23504326. 
  2. ^ He W, Miao FJ, Lin DC, Schwandner RT, Wang Z, Gao J, Chen JL, Tian H, Ling L (May 2004). "Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors". Nature 429 (6988): 188–93. doi:10.1038/nature02488. PMID 15141213. 
  3. ^ Wittenberger T, Hellebrand S, Munck A, Kreienkamp HJ, Schaller HC, Hampe W (Jul 2002). "GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors". BMC Genomics 3: 17. doi:10.1186/1471-2164-3-17. PMC 117779. PMID 12098360. 
  4. ^ a b "Entrez Gene: OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1". 

Further reading[edit]

  • Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Inbe H, Watanabe S, Miyawaki M, Tanabe E, Encinas JA (May 2004). "Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine". The Journal of Biological Chemistry 279 (19): 19790–9. doi:10.1074/jbc.M400360200. PMID 15001573. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.