Oil of clove

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Clove (Syzygium aromaticum) essential oil in clear glass vial

Oil of clove, also known as clove oil, is an essential oil extracted from the clove plant, Syzygium aromaticum.[1] Clove oil is commonly used in aromatherapy and for flavoring food and some medicines.[2] Madagascar and Indonesia are the main producers of clove oil.[3]

Although it may be promoted as having analgesic properties, there is insufficient medical evidence to support such uses.[1][2]

Types and phytochemicals[edit]

There are three types of clove oil:[3]

  • Bud oil is derived from the flower-buds of S. aromaticum. It consists of 60–90% eugenol, acetyl eugenol, caryophyllene and other minor constituents.
  • Leaf oil is derived from the leaves of S. aromaticum. It consists of 82–88% eugenol with little or no eugenyl acetate, and minor constituents.
  • Stem oil is derived from the twigs of S. aromaticum. It consists of 90–95% eugenol, with other minor constituents.

Distilled clove oil from buds contains mixed phytochemicals, including as main constituents phenylpropanoids (primarily eugenol), carvacrol, thymol, and cinnamaldehyde, with smaller quantities of polyphenols, carbohydrates, lipids, oleanolic acid, and rhamnetin.[1]



Particularly in South Korea and India, eugenol, a phytochemical extracted from clove oil, is used to relieve toothache.[4] Applied to a cavity in a decayed tooth or tooth socket remaining after extraction, eugenol or clove oil may relieve toothache temporarily.[4] In the United States, the FDA considers eugenol ineffective for treating dental pain, and has downgraded clove oil as an analgesic due to insufficient evidence to rate its effectiveness.[2]


Clove oil is commonly used to anesthetize or euthanize laboratory or pet fish.[5][6]


In Australia, clove oil is one of several essential oils implicated with poisoning, mostly of children. In the period 2014-2018, there were 179 cases in New South Wales, accounting for 4% of essential oil poisoning incidents.[7]


In Germany, Commission E permits the sale and administration of clove oil as a medicinal herb.[8]


  1. ^ a b c "Clove". Drugs.com. 3 July 2020. Retrieved 27 September 2020.
  2. ^ a b c "Clove". MedlinePlus, National Library of Medicine, US National Institutes of Health. 24 July 2020. Retrieved 27 September 2020. Clove oil and eugenol, one of the chemicals it contains, have long been used topically for toothache, but the FDA has reclassified eugenol, downgrading its effectiveness rating. The FDA now believes there isn't enough evidence to rate eugenol as effective for toothache pain.
  3. ^ a b Lawless, J. (1995). "The Illustrated Encyclopedia of Essential Oils: The Complete Guide to the Use of Oils in Aromatherapy and Herbalism". The Illustrated Encyclopaedia of Essential Oils. ISBN 978-1-85230-661-8.
  4. ^ a b Chung G, Oh SB (2013). "Eugenol as Local Anesthetic". Natural Products. Springer-Verlag Berlin; In: Natural Products - Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes; Part XIV. pp. 4001–4015. doi:10.1007/978-3-642-22144-6_171. ISBN 978-3-642-22144-6.CS1 maint: uses authors parameter (link)
  5. ^ Gary Kent Ostrander (2000). The Laboratory Fish. Elsevier. pp. 508–. ISBN 978-0-12-529650-2.
  6. ^ Gary West; Darryl Heard; Nigel Caulkett (21 July 2014). Zoo Animal and Wildlife Immobilization and Anesthesia. Wiley. pp. 249–. ISBN 978-1-118-79286-5.
  7. ^ Lee KA, Harnett JE, Cairns R (2019). "Essential oil exposures in Australia: analysis of cases reported to the NSW Poisons Information Centre". Medical Journal of Australia. doi:10.5694/mja2.50403. ISSN 0025-729X. Lay summary.
  8. ^ Rister, R.; Klein, S.; Riggins, C. (1998-08-15). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines (1st ed.). American Botanical Council. p. 112. ISBN 978-0-9655555-0-0.