Biopsy specimen of a Oligoastrocytoma (HE stain)
|Classification and external resources|
Oligoastrocytomas are a subset of brain tumors that present with an appearance of mixed glial cell origin, astrocytoma and oligodendroglioma. These types of glial cells that become cancerous are involved with insulating and regulating the activity of neuron cells in the central nervous system. Often called a "mixed glioma", about 2.3% of all reported brain tumors are diagnosed as oligoastrocytoma. The median age of diagnosis is 42 years of age. Oligoastrocytomas, like astrocytomas and oligodendrogliomas, can be divided into low-grade and anaplastic variant, the latter characterized by high cellularity, conspicuous cytologic atypism, mitotic activity and, in some cases, microvascular proliferation and necrosis.
However, lower grades can have less aggressive biology.
These are largely supratentorial tumors of adulthood that favor the frontal and temporal lobes.
A Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) scan is necessary to characterize the anatomy of this tumor as to size, location, and its heter/homogeneity. However, final diagnosis of this tumor, like most tumors, relies on histopathologic examination (biopsy examination).
If resected, the surgeon will remove as much of this tumor as possible, without disturbing eloquent regions of the brain (speech/motor cortex) and other critical brain structure. Thereafter, treatment may include chemotherapy and radiation therapy of doses and types ranging based upon the patient's needs. Subsequent MRI examination are often necessary to monitor the resection cavity.
Even after surgery, an oligoastrocytoma will often recur. The treatment for a recurring brain tumor may include surgical resection, chemo and radiation therapy. Survival time of this brain tumor varies - younger age and low-grade initial diagnosis are factors in improved survival time.
- Hiremath GK, Bingaman WE, Prayson RA, Nair D (September 2007). "Oligoastrocytoma presenting with intractable epilepsy". Epileptic Disord 9 (3): 315–22. doi:10.1684/epd.2007.0117. PMID 17884756.
- Samantha Dickson Brain Tumour Trust: brain tumour research and support charity
- SDBTT Astro Fund, funding research and offering support to those affected by low-grade oligoastrocytomas
- Brain and Spinal Tumors: Hope Through Research from the U.S. (National Institute of Neurological Disorders and Stroke)
- Images from the Uniformed Services University of the Health Sciences