In enzymology, an omega-amidase (EC 18.104.22.168) is an enzyme that catalyzes the chemical reaction
- a monoamide of a dicarboxylic acid + H2O a dicarboxylate + NH3
Thus, the two substrates of this enzyme are monoamide of a dicarboxylic acid and H2O, whereas its two products are dicarboxylate and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is omega-amidodicarboxylate amidohydrolase. This enzyme is also called alpha-keto acid-omega-amidase. This enzyme participates in glutamate metabolism and alanine and aspartate metabolism.
- MEISTER A, LEVINTOW L, GREENFIELD RE, ABENDSCHEIN PA (1955). "Hydrolysis and transfer reactions catalyzed by omega-amidase preparations". J. Biol. Chem. 215 (1): 441–60. PMID 14392177.
- Meister A, Radhakrishnan AN, Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline". J. Biol. Chem. 229 (2): 789–800. PMID 13502341.