Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.  
OSMR is a member of the
type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. 
Clinical significance [ edit ]
The oncostatin M receptor is associated with
primary cutaneous amyloidosis. 
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000145623 - Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022146 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ a b "Entrez Gene: oncostatin M receptor".
^ Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. doi: 10.1074/jbc.271.51.32635. PMID 8999038.
^ Arita K, South AP, Hans-Filho G, et al. (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. doi: 10.1016/j.ajhg.2007.09.002. PMC . 2253984 PMID 18179886.
External links [ edit ]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.