The square lies between the Old Brompton Road to the northwest and the Fulham Road to the southeast. To the north is South Kensington tube station. To the south is the Royal Marsden Hospital. As well as the main square, the address covers the street to the southwest that turns into Onslow Gardens, and the street to the northwest that meets Pelham Street by South Kensington tube station.
The houses were built by Charles James Freake, on land belonging to the Smith's Charity Estate. His building agreement with the trustees of the charity stipulated that they should be stuccoed, and constructed to elevational designs and specifications provided by the trustees' architect and surveyor, George Basevi. The first four houses in the square, numbers 1,3,5, and 7, were begun in September 1845, and were occupied by 1847. The whole square was completed by 1865.
After the building of the first four houses, and Basevi’s sudden death in 1845, the style of the houses diverged from the agreed designs, using exposed grey stock brick, with only the dressings being of stucco.
St Paul's Church
St Paul's Church in Onslow Square was created as a part of Sir Charles James Freake's development of the square. The church was built during 1859–60, designed by James Edmeston together with Charles Freake's office. In 1876, a church hall was constructed south of the church. This was extended in 1893. The church is now administered by Holy Trinity Brompton Church.
The novelist William Makepeace Thackeray lived at 36 Onslow Square from 1853 to 1860. Here he wrote the last part of The Newcomes, the Lectures on the Four Georges, The Virginians, and some of The Adventures of Philip and The Roundabout Papers.
Vice-Admiral Robert FitzRoy (1805–1865), commander of HMS Beagle, on board which the naturalist Charles Darwin (1809–1882) also sailed, lived at 38 Onslow Square. Fitzroy lived at No 38 from 1854 to 1865, when he committed suicide, through guilt for his part in casting doubt about the truth of the Bible.
Edmund Fisher (1872–1918), British architect, was born in Onslow Square.
John Parker (1799–1881), a barrister and Whig politician, died at 57 Onslow Square.
The architect William Railton, designer of Nelson’s Column, lived at 65 Onslow Square. His daughter married Rev. Barclay Fowell Buxton (1860–1946), who was curate at Onslow Square from 1884 to 1887. The sculptor Baron Carlo Marochetti - who cast the lions for the column - lived at number 34, and had a workshop and foundry nearby in Sydney Mews.
- Onslow Square Guide — South Kensington, London SW7, LondonTown.com.
- F. H. W. Sheppard (General Editor) (1983). "The Smith's Charity Estate: Charles James Freake and Onslow Square Gardens". Survey of London: volume 41: Brompton. Institute of Historical Research. Retrieved 6 October 2011.
- "Holy Trinity Brompton — History: A Church for a Community". Holy Trinity Brompton. 2010-08-01.
- Charles James Freake and Onslow Square and Gardens, British History, English Heritage, UK.
- William Makepeace Thackeray: 1853 — Onslow Square, London, University of Pennsylvania Libraries.
- Richard Jones, A London Walk in Chelsea, London Walking Tours.