The orb rests in Doctor Strange's Sanctum Sanctorum in a room called the Chamber of Shadows. It usually is inside a display case with three curved legs. When summoned, the glass covering rises and the ball levitates.
While powerful, the Orb has been blocked by exceptionally powerful mystic forces (such as Umar) who do not want their exact location known.
On at least one occasion, it has been used to open a dimensional portal, to the realm of Agamotto.
The Orb had a cameo appearance in the 2011 film Thor.