Org 37,684

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Org 37,684
Org37684 structure.png
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
Chemical and physical data
Formula C14H19NO2
Molar mass 233.305 g/mol
3D model (Jmol)
  (verify)

Org 37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.[1][2] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.[3]

See also[edit]

References[edit]

  1. ^ Adams, D.; Duncton, M. (2001). "EFFICIENT SYNTHESIS OF THE 5-HT2C RECEPTOR AGONIST, ORG 37684". Synthetic Communications. 31 (13): 2029–2036. doi:10.1081/SCC-100104420. 
  2. ^ Knight, AR; Misra, A; Quirk, K; Benwell, K; Revell, D; Kennett, G; Bickerdike, M (2004). "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn Schmiedebergs Archives of Pharmacology. 370 (2): 114–123. doi:10.1007/s00210-004-0951-4. PMID 15322733. 
  3. ^ Schreiber, R; De Vry, J (April 2002). "Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat". Prog. Neuropsychopharmacol. Biol. Psychiatry. 26 (3): 441–9. doi:10.1016/s0278-5846(01)00284-6. PMID 11999893.