Organ of Zuckerkandl
|Organ of Zuckerkandl|
The abdominal aorta and its branches. (Organ of Zuckerkandl is not shown, but it usually appears alongside the abdominal aorta.)
The organ of Zuckerkandl is a chromaffin body derived from neural crest located at the bifurcation of the aorta or at the origin of the inferior mesenteric artery. It can be the source of paraganglioma.
The term para-aortic body is also sometimes used to describe it, as it usually arises near the abdominal aorta, but this term can be the source of confusion, because the term "corpora paraaortica" is also used to describe the aortic body, which arises near the thoracic aorta. This diffuse group of neuroendocrine sympathetic fibres was first described by Emil Zuckerkandl, a professor of anatomy at the University of Vienna, in 1901.
Some sources equate the "aortic bodies" and "paraaortic bodies", while other sources explicitly distinguish between the two. When a distinction is made, the "aortic bodies" are chemoreceptors which regulate circulation, while the "paraaortic bodies" are the chromaffin cells which manufacture catecholamines.
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The organ of Zuckerkandl is of pathological significance in the adult as a common extra-adrenal site of pheochromocytoma though the most common extra-adrenal site is in the superior para-aortic region between the diaphragm and lower renal poles.
In addition to its endocrine effects, it can also cause obstructive pathology.
- Dossett, Lesly; Rudzinski, Erin; Blevins, Lewis; Chambers, Eugene (2007). "Malignant Pheochromocytoma of the Organ of Zuckerkandl Requiring Aortic and Vena Caval Reconstruction". Endocrine Practice. 13 (5): 493–7. doi:10.4158/ep.13.5.493. PMID 17872352.
- synd/3111 at Who Named It?
- "organs of Zuckerkandl" at Dorland's Medical Dictionary
- Aortic Bodies at the US National Library of Medicine Medical Subject Headings (MeSH)
- Para-Aortic Bodies at the US National Library of Medicine Medical Subject Headings (MeSH)
- Schober, Andreas; Parlato, Rosanna; Huber, Katrin; Kinscherf, Ralf; Hartleben, Björn; Huber, Tobias B.; Schütz, Günther; Unsicker, Klaus (2013). "Cell Loss and Autophagy in the Extra-Adrenal Chromaffin Organ of Zuckerkandl are Regulated by Glucocorticoid Signalling". Journal of Neuroendocrinology. 25 (1): 34–47. doi:10.1111/j.1365-2826.2012.02367.x. ISSN 0953-8194. PMC . PMID 23078542.
- Saurborn, Daniel P.; Kruskal, Jonathan B.; Stillman, Isaac E.; Parangi, Sareh (2003). "Best Cases from the AFIP". RadioGraphics. 23 (5): 1279–86. doi:10.1148/rg.235035022. PMID 12975514.
- Whalen, R. K.; Althausen, A. F.; Daniels, G. H. (1992). "Extra-adrenal pheochromocytoma". The Journal of Urology. 147 (1): 1–10. PMID 1729490.
- Thompson, Robert W. (2002). "Detection and Management of Small Aortic Aneurysms". New England Journal of Medicine. 346 (19): 1484–6. doi:10.1056/NEJM200205093461910. PMID 12000820.
- Kravarusic, Dragan; Pinto-Rojas, Alfredo; Al-Assiri, Ali; Sigalet, David (2007). "Laparoscopic resection of extra-adrenal pheochromocytoma—Case report and review of the literature in pediatric patients". Journal of Pediatric Surgery. 42 (10): 1780–4. doi:10.1016/j.jpedsurg.2007.06.025. PMID 17923216.
- Blecha, Matthew; Galanopolous, Christos; Dharkar, Dilip; Salti, George (2005). "Massive Organ of Zuckerkandl Inducing Small Bowel Obstruction". Journal of the American College of Surgeons. 201 (3): 480–1. doi:10.1016/j.jamcollsurg.2005.02.031. PMID 16125084.