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Many of these compounds are toxic, and some are used as pesticides.
These variants with P=S double bonds, of organophosphates with P=O double bonds, were developed as insecticides because of their reduced mammalian toxicity, an important safety factor; the phosphorothioate P=S bond is converted to the toxic P=O bond in the target insect. Similar oxidative conversion in mammals is slower, conferring lower toxicity in mammals.
Examples of these include:
However, several others have medical uses, including:
- Organothiophosphorus Compounds at the US National Library of Medicine Medical Subject Headings (MeSH)
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