Vascular organ of lamina terminalis

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Vascular organ of lamina terminalis
Latin organum vasculosum laminae terminalis
NeuroNames hier-366
NeuroLex ID Organum vasculosum lamina terminalis
TA A14.1.08.940
FMA 62315
Anatomical terms of neuroanatomy

The vascular organ of lamina terminalis (or supraoptic crest) is one of the circumventricular organs of the brain. Other circumventricular organs are the subfornical organ (SFO) and the area postrema in the brainstem.

AV3V region[edit]

The vascular organ of the lamina terminalis and the SFO are both strongly interconnected with the median preoptic nucleus of the hypothalamus (the nucleus medianus), and together these three structures comprise the "anterioventral third ventricle (AV3V) region" -- the region anterior and ventral to the third ventricle. The AV3V region is very important in the regulation of fluid and electrolyte balance by controlling thirst, sodium excretion, blood volume regulation, and vasopressin secretion.


The vascular organ of the lamina terminalis lacks a blood brain barrier, and so neurons in this region can respond to osmotic pressure factors that are present in the systemic circulation.[1]

Some neurons in this organ are osmoreceptors, being sensitive to the osmotic pressure of the blood. These neurons project to the supraoptic nucleus and paraventricular nucleus to regulate the activity of vasopressin-secreting neurons. In a situation of lowered blood volume, secretion of renin by the kidneys results in the production of angiotensin II, which stimulates the vascular organ and the subfornical organ to complete a positive feedback loop.[2] These neurons also project to the nucleus medianus (also called the medial preoptic nucleus) which is involved in controlling thirst.


  1. ^ Koeppen, Bruce M. (2010). Berne & Levy Physiology 6th Edition Updated Edition. pp. 228–229. ISBN 978-0-323-07362-2. 
  2. ^ FITZGERALD, M J Turlough (2012). Clinical Neuroanatomy and Neuroscience. Philadelphia: Saunders Elsevier. p. 281. ISBN 978-0-7020-3738-2. 

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