Orly Goldwasser received her B.A. at Tel Aviv University, continued studying at the Hebrew University in Jerusalem, where she was awarded her M.A. and PhD degrees. She occupies the chair of Egyptology at the Hebrew University, and is a Honorary Professor at the University of Göttingen, she was guest professor at the University of Göttingen, Harvard University and at the Collège de France.
Her main interests are the semiotics of the hieroglyphic script, intercultural relations: Egypt and the Levant, metaphors and literary images in ancient Egyptian literature and the origin of the alphabet. She is the discoverer of the classification system in the hieroglyphic script.