This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is L-ornithine ammonia-lyase (cyclizing; L-proline-forming). Other names in common use include ornithine cyclase, ornithine cyclase (deaminating), and L-ornithine ammonia-lyase (cyclizing). This enzyme participates in arginine and proline biosynthesis. It employs one cofactor, NAD+.
Costilow RN, Laycock L (1971). "Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions". J. Biol. Chem.246 (21): 6655–60. PMID4399881.
Muth WL, Costilow RN (1974). "Ornithine cyclase (deaminating). II. Properties of the homogeneous enzyme". J. Biol. Chem.249 (23): 7457–62. PMID4373469.
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE (2004). "Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family". Biochemistry. 43 (44): 13883–91. PMID15518536. doi:10.1021/bi048207i.