Ornithine cyclodeaminase

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ornithine cyclodeaminase
Identifiers
EC number 4.3.1.12
CAS number 9054-76-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an ornithine cyclodeaminase (EC 4.3.1.12) is an enzyme that catalyzes the chemical reaction

Ornithine cyclodeaminase.svg
L-ornithine \rightleftharpoons L-proline + NH4

Hence, this enzyme has one substrate, L-ornithine, and two products, L-proline and NH4.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is L-ornithine ammonia-lyase (cyclizing; L-proline-forming). Other names in common use include ornithine cyclase, ornithine cyclase (deaminating), and L-ornithine ammonia-lyase (cyclizing). This enzyme participates in arginine and proline biosynthesis. It employs one cofactor, NAD+.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1U7H and 1X7D.

References[edit]