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Orsini is a surname of Italian origin, ultimately derived from Latin ursinus ("bearlike") and originating as an epithet or sobriquet describing the name-bearer's purported strength. Notable people with the surname include the following:
- Orsini family, Italian noble family.
- Alessandro Orsini (1592–1626), cardinal.
- Angel Orsini, American professional wrestler and bodybuilder.
- Clarice Orsini (1453–1488), mother of Pope Leo X.
- Felice Orsini (1819–1858), Italian revolutionary who attempted to assassinate Napoléon III.
- Francesca Orsini, Italian scholar of South Asian literature.
- Fulvio Orsini (1529–1600), Italian historian.
- Giordano Orsini (died 1438), 15th-century Italian cardinal.
- Giordano Orsini (died 1173), Catholic prelate .
- Giorgio Orsini (1410–1475), architect and sculptor.
- Pope Nicholas III, born Giovanni Gaetano Orsini.
- Giovanni Gaetano Orsini (cardinal) (c.1285–1335), nephew of Pope Nicholas III.
- John II Orsini (died 1335), known as the Despot of Epirus.
- Latino Orsini (1411–1477), Catholic cardinal.
- Latino Malabranca Orsini (d. 1294), Catholic prelate.
- Marina Orsini (born 1967), Canadian actress.
- Matteo Orsini (d. 1340), Catholic prelate.
- Napoleone Orsini (1420–1480), condottiero and papal commander.
- Nicola Orsini (1331–1399), Count of Nola, Senator of Rome .
- Paolo Giordano Orsini (disambiguation).
- Pope Benedict XIII, born Pietro Francisco Orsini.
- Rinaldo Orsini (d. 1450), Lord of Piombino.
- Umberto Orsini (born 1934), stage, television and film actor.
- Valentino Orsini (1927–2001), film director.
- Virginio Orsini (1434–1497), Lord of Bracciano.
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