Osler's node

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Osler's lesions found on the hand and fingers of a 43-year-old male with subacute bacterial endocarditis.

Osler's nodes are painful, red, raised lesions found on the hands and feet. They are associated with a number of conditions, including infective endocarditis, and are caused by immune complex deposition. Their presence is one definition of Osler's sign.[1]


Osler's nodes result from the deposition of immune complexes.[2] The resulting inflammatory response leads to swelling, redness, and pain that characterize these lesions.

The nodes are commonly indicative of subacute bacterial endocarditis.[3] 10–25% of endocarditis patients will have Osler's nodes.[citation needed] Other signs of endocarditis include Roth's spots and Janeway lesions. The latter, which also occur on the palms and soles, can be differentiated from Osler's nodes because they are non-tender.[2]

Osler's nodes can also be seen in


Osler's nodes are named after Sir William Osler who described them in the early 20th century.[4][5]

External links[edit]


  1. ^ "Osler sign" at Dorland's Medical Dictionary
  2. ^ a b Farrior, JB; Silverman, ME (August 1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis" (PDF). Chest. 70 (2): 239–43. doi:10.1378/chest.70.2.239. PMID 947688.
  3. ^ "Osler nodes" at Dorland's Medical Dictionary
  4. ^ synd/1702 at Who Named It?
  5. ^ Osler, W (1908–1909). "Chronic infectious endocarditis". Quarterly Journal of Medicine. Oxford. 2: 219–230.