Osmosis Jones

This article is about the film. For the soundtrack list, see Osmosis Jones (soundtrack). For other uses of Osmosis, see Osmosis (disambiguation).

Osmosis Jones
Theatrical release poster
Directed by	Animation: Tom Sito Piet Kroon Live-action: Robert Farrelly Peter Farrelly
Produced by	Dennis Edwards Robert Farrelly Peter Farrelly Zak Penn Bradley Thomas
Written by	Marc Hyman
Starring	Chris Rock Laurence Fishburne David Hyde Pierce Brandy William Shatner Molly Shannon Chris Elliott Bill Murray
Music by	Randy Edelman
Cinematography	Mark Irwin
Edited by	Lois Freeman-Fox Stephen Schaffer Sam Seig
Production company	Warner Bros. Feature Animation Conundrum Entertainment
Distributed by	Warner Bros. Pictures
Release date	August 7, 2001 (2001-08-07) (premiere) August 10, 2001 (2001-08-10) (United States)
Running time	95 minutes
Country	United States
Language	English
Budget	$70 million
Box office	$14 million

Osmosis Jones is a 2001 American live-action/animated buddy cop comedy film with animated scenes directed by Tom Sito and Piet Kroon and live-action scenes directed by the Farrelly brothers. The film centers on Frank Detorre, a slovenly zookeeper; the live-action scenes are set outside Frank's body, while the animated scenes are set inside his body, which is portrayed as a city inhabited by anthropomorphic microorganisms. White blood cell cop Osmosis "Ozzy" Jones and cold pill Drix must prevent deadly virus Thrax from killing Frank within forty-eight hours.

The film was met with mixed reviews, with critics praising the animated portions but criticizing the live-action portions and their use of gross-out humor. The film was a box office bomb, earning $14 million against a budget of $70 million, though it later sold well in home media. It also served as the pilot to the Kids' WB television series Ozzy & Drix (2002–04), where Ozzy and Drix get transferred by a mosquito to the body of a teenage boy named Hector and continue their battle against germs and viruses from there.

Plot

Frank Detorre (Bill Murray) is an unkempt, slovenly zookeeper at the Sucat Memorial Zoo in Rhode Island. Depressed by the loss of his wife years earlier, he copes by unhealthy eating and ignoring basic hygiene, to the annoyance of his young daughter Shane (Elena Franklin).

Inside the body, Osmosis "Ozzy" Jones (Chris Rock) is a rebellious white blood cell officer of the Frank PD, who was fired from his job working in the kidneys and was demoted to patrol duty in the mouth after an incident at the science fair where he caused Frank to accidentally vomit on Shane's science and P.E. teacher, Mrs. Boyd (Molly Shannon) after being the only one who has seen the virus in one of the oysters Frank ate from Zach's oyster project. Facing a challenge to his re-election prospects, Mayor Phlegmming (William Shatner) doubles down on his junk-food policies, ignoring their effect on Frank's health. This causes Frank to eat a boiled egg covered in filth, allowing Thrax (Laurence Fishburne), a deadly virus, to enter the throat. Unwilling to admit responsibility, Phlegmming instructs Frank to take a cold pill through brain signals. The suppressant, Drixenol "Drix" Koldreliff (David Hyde Pierce), proceeds to disinfect the throat, covering up any evidence of Thrax's arrival. To his displeasure, Ozzy is subsequently assigned to assist Drix in his investigation.

Thrax assumes leadership of a gang of sweat germs and launches an attack on the mucus dam in Frank's nose, nearly killing Ozzy and Drix before Frank inhales them into the sinuses. Based on information from one of his informants, Ozzy goes undercover at a nightclub intending to infiltrate Thrax's gang, only to be discovered and forced to call in Drix, who manages to destroy the club and presumably kill Thrax with a grenade. The explosion pops a zit on Frank's forehead during a meeting with Mrs. Boyd which lands on her lip, ruining any chance for him to apologize. In response, Phlegmming closes the investigation, fires Ozzy and orders Drix to leave the city.

Having survived the assault, Thrax breaks into the hypothalamus gland and steals a DNA bead from a chromosome. His actions disable the body's ability to regulate temperature, causing the city to break out in flames and panic. He kidnaps the Mayor's secretary, Leah Estrogen (Brandy), and flees to the mouth to escape. As Frank is taken to the hospital in a fever coma, Ozzy and Drix reconcile and proceed to rescue Leah, but Thrax escapes using pollen to make Frank sneeze him out. Ozzy pursues him to the surface of Shane's left eye, and as they fight they land on Shane's left false eyelash when she blinks. As Thrax has Ozzy pinned down, he threatens to break his own record by killing Shane but gets stuck in the false eyelash; Ozzy escapes at the last minute before the eyelash slides off and lands in a cup of alcohol, dissolving Thrax to death.

As Frank's temperature goes over 108 degrees, his heart begins to shut down. Riding one of Shane's tears, Ozzy reenters Frank's body with Thrax's necklace of DNA beads, reviving him just in time. Having narrowly cheated death, Frank commits himself to living a healthier lifestyle for himself and Shane, while Ozzy is re-instated to the force with Drix as his new partner, and begins a relationship with Leah. Phlegmming later loses his position as mayor, is reduced to working as a custodian in the bowels, and accidentally ejects himself by pushing a button that triggers Frank's flatulence.

Cast

Animation voice cast

• Chris Rock as Osmosis "Ozzy" Jones, an overzealous blue and white blood cell with little respect for authority. Since he was discredited, he was suspended for unnecessary force and placed in out-of-the-way patrols. Therefore, he seizes any opportunity to be able to make a difference. He is able to combine his eyes into one, to ooze through narrow spaces like cracks and under doors, and to contort his body.
• Laurence Fishburne as Thrax, a tall, extremely virulent, pathogenic agent. Thrax is referred to as "The Red Death" (a common nickname for the ebola virus) but does not appear to cause an existing disease, although he claims loudly, "Ebola is a case of dandruff compared to me!", and has killed numerous people before arriving in Frank. He carries a chain consisting of numerous chromosomes removed from other victims' hypothalamus as a trophy. His left index finger is a long claw, which can melt the cellular equivalent of steel, consume cells and other viruses in flames, and alter the properties of other cells.
• David Hyde Pierce as Drixenol "Drix" Koldreliff, a stoic cold pill who becomes Ozzy's best friend. His right arm is a cannon used to shoot an assorted variety of medication, including one that freezes any target. He is a follower of written rules and compensates for his doubts of himself by acting haughtily. He is intelligent, clever, and dedicated to work. Straight-laced and by-the-book, he is in disagreement with the crude humor and unorthodox methods of Ozzy, but respects Ozzy as a partner due to his dedication to fighting diseases.
• Brandy as Leah Estrogen, Mayor Phlegmming's secretary and Ozzy's love interest, greatly relied upon by him for her skills. She is one of few inhabitants of Frank who realize the flaws of the current administration and one of the few willing to believe Osmosis' claims of a large-scale infection. Her name has the word Estrogen which is a hormone mostly present in female people but can be present in males as well.
• William Shatner as Mayor Phlegmming, the short, overweight, and self-centered mayor of the "City of Frank". He is constantly preoccupied with everything but his job, except when it concerns planning his re-election. His name is a pun on the word phlegm.
• Ron Howard as Tom Colonic, Phlegmming's rival for the mayoralty of the City of Frank. His political platform is diametrically opposed to the incumbent's, instead promoting less junk food and a healthier "City of Frank". His manner and attitude appears to be modeled after President John F. Kennedy. His name represents an organ called the colon.
• Joel Silver as the Police Chief, Ozzy's boss who works at the precinct.

Live-action cast

• Bill Murray as Frank Detorre, a widower in his 40s who works as a zookeeper. He is prone to eating junk food, behaves laconically, and has minimal concern for his health. The animated part of the film takes place inside his body, which is referred to by the cells as "the City of Frank".
• Elena Franklin as Shane Detorre, Frank's 10-year-old daughter. Due to her father's shortcomings, his health is very important to her. She has become somewhat depressed after her mother's death, and as a result her relationships with other people are suffering.
• Molly Shannon as Mrs. Boyd, Shane's science and P.E. teacher. Having had her reputation and those of her oldest daughter Shirley and two younger sons Ralph and Chuck ruined after her embarrassment by a vomiting accident Frank caused due to a misunderstanding about oyster consumption, she has a 200-yard restraining order against him to prevent any further embarrassment. At the end, she gave up the 200-yard restraining order and lets him and Shane go on the father/daughter camping/hiking trip, but is still upset at Frank about the incident.
• Chris Elliott as Bob Detorre, Frank's brother and Shane's uncle. Two years ago, after Frank got fired from his job at the pea soup factory due to the oyster vomiting incident, Bob hired him at his zoo.

Production

Osmosis Jones went through development hell during production. The animated sequences, directed by Tom Sito and Piet Kroon, went into production as planned, but acquiring both a director and a star actor for the live-action sequences took a considerable amount of time, until Bill Murray was cast as the main character of Frank, and Peter and Bobby Farrelly stepped in to direct the live-action sequences. As part of their contract, the Farrelly brothers are credited as the primary directors of the film, although they did no supervision of the animated portions of the film. Will Smith was interested in the part, but in the end his schedule didn't permit it.

Osmosis Jones was originally rated PG-13 for "crude language" and "bodily humor" in 2000. Warner Bros. edited the film to make it family-friendly, and in 2001 the film was re-rated PG for "bodily humor".

Release

Box office

Osmosis Jones opened on August 10, 2001 in 2,305 theaters worldwide. Upon its original release, the film lost a considerable amount of money, and was the second-to-last production for Warner Bros.' feature traditional animation department (following The Iron Giant, and followed by Looney Tunes: Back in Action, which both also lost money upon their original releases). The movie opened at #7 in its first opening weekend at the U.S. box office, accumulating $5,271,248 on its opening week while earning $2,286. The film soon grossed $13,596,911.

Reception

Osmosis Jones received mixed reviews from film critics. Based on 108 reviews collected by Rotten Tomatoes, 55% of critics gave the film positive reviews, with an average rating of 5.5/10. Their consensus reads, "The animated portion of Osmosis is zippy and fun, but the live-action portion is lethargic." At Metacritic, which assigns a weighted average rating out of 100 to reviews from mainstream critics, the film has received an average score of 57 based on 28 reviews. The animated parts of Osmosis Jones were praised for their plot and fast pace, in contrast with the criticized live action segments, with Rotten Tomatoes' consensus of the film stating, "The animated portion of Osmosis is zippy and fun, but the live-action portion is lethargic." Robert Koehler of Variety praised the film for its animated and live-action segments intervening, claiming it to be "the most extensive interplay of live action and animation since Who Framed Roger Rabbit". The New York Times wrote "the film, with its effluvia-festival brand of humor, is often fun, and the rounded, blobby rendering of the characters is likable. But the picture tries too hard to be offensive to all ages. I suspect that even the littlest viewers will be too old for that spit." Roger Ebert gave the film 3 stars out of 4.

The use of crude humor in Osmosis Jones, as done in most films directed by the Farrelly brothers, was widely criticized. As such, Lisa Alspector of Chicago Reader described the film as a "cathartically disgusting adventure movie". Maitland McDonagh of TV Guide praised the film's animation and its glimpse of intelligence although did criticize the humor as being "so distasteful". Lisa Schwarzbaum of Entertainment Weekly felt that the film had a diverse premise as it "oscillates between streaky black comedy and sanitary instruction", however the scatological themes were again pointed out. Jonathan Foreman of New York Post claimed Osmosis Jones to have generic plotting, saying that "It's no funnier than your average grade-school biology lesson and less pedagogically useful than your typical Farrelly brothers comedy." Chris Hewitt of Miami Times described Chris Rock's, Brandy Norwood's and Laurence Fishburne's voice work as Osmosis, Leah and Thrax respectively as "classy" although considered the film to be politically correct as all three of these actors are African-American. Michael Sragow of Baltimore Sun praised David Hyde Pierce's performance as Drix, claiming him to be "hilarious" and "a take-charge dose of medicine". Despite of the mixed reviews, the film received numerous Annie award nominations including Best Animated Feature (losing to Shrek)

Soundtrack

Main article: Osmosis Jones (soundtrack)

A soundtrack containing hip hop and R&B music was released on August 7, 2001 by Atlantic Records. The soundtrack failed to make it to the Billboard charts, but Trick Daddy's single "Take It to da House" managed to make it to 88 on the Billboard Hot 100 singles chart.

See also

• Once Upon a Time... Life, an animated series with similar anthropomorphic representations of cells and germs.

External links

• Osmosis Jones on IMDb
• Osmosis Jones at The Big Cartoon DataBase