The Oti River or Pendjari River is an international river in West-Central Africa.
The river's headwaters are in Burkina Faso, and it is a tributary of the Volta River in Ghana. The Oti River also flows through Benin and Togo. One of its eastern tributaries is the Kara River.
The river mouth, formerly on the Volta River, is now at Lake Volta reservoir in Ghana.
- International borders
The river forms part of the international borders between Ghana, Burkina Faso, Togo, and Benin.
The Oti River flows through Pendjari National Park in Benin.