Ottaviano de' Medici (July 11, 1484 – May 28, 1546) was an Italian politician and statesman, ancestor of the Princes of Ottaiano line of the Medici family.
He held several important positions in Florence, including that of Gonfaloniere di Giustizia, although now a merely formal one after the suppression of the Republic by the Spanish troops in 1530. He was also Senator from 1532.
His son Alessandro was cardinal and, from 1605, pope as Leo XI. His other son Bernadetto founded the southern Italian line of the family by acquiring the seigniory of Ottaiano, near Naples.