He held several important positions in Florence, including that of Gonfaloniere di Giustizia, although now a merely formal one after the suppression of the Republic by the Spanish troops in 1530. He was also Senator from 1532. He was trusted by Alessandro de' Medici with administrating the family's Tuscan estates.
His son Alessandro was cardinal and, from 1605, pope as Leo XI. His other son Bernadetto founded the southern Italian line of the family by acquiring the seigniory of Ottaiano, near Naples.