With Carl Woese Kandler proposed the change from the preceding view of living organisms as a Two-empire system of Prokaryotes and Eukaryotes to the Three-domain system of the domains Eukaryota, Bacteria and Archaea. While bacteria and archaea appear to be similar in form and structure, Woese, Kandler and Wheelis demonstrated that they were genetically very dissimilar. They demonstrated this through analysis of Ribosomal RNA.
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