Ottoman wars in the Near East
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When Beyazid II was enthroned upon his father's death, he first had to fight his younger brother Cem Sultan, who took Inegöl and Bursa and proclaimed himself Sultan of Anatolia. After a battle at Yenişehir, Cem was defeated and fled to Cairo. The very next year he returned, supported by the Mameluks, and took eastern Anatolia, Ankara and Konya but eventually he was beaten and forced to flee to Rhodes.
After a first indecisive conflict, Selim I defeated the Mamelukes and conquered most of modern Syria, Lebanon, Palestine and Egypt, including the holy city of Jerusalem as well as Cairo, the residence of the Abbasid caliph. He also began a series of wars with the Safavid Dynasty (see Ottoman–Persian Wars).